Degradation of lipid based drug delivery formulations during nebulization
نویسندگان
چکیده
منابع مشابه
Aerosol delivery during continuous nebulization.
BACKGROUND AND OBJECTIVES Continuous administration of aerosolized beta 2-agonists has been suggested as an effective treatment for severe reversible airways disease. To facilitate continuous therapy and avoid a feed system for small-volume nebulizers (SVNs), a large-volume medication nebulizer (Vortran HEART) was developed. The goal of this study was to determine actual drug delivery of the HE...
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More than 60% of drugs have lipophilic nature and exhibit poor water-solubility. The dissolution is the rate limiting step in their absorption and oral bioavailability. To overcome this problem one approach to enhance dissolution is Self-Dispersing Lipid Formulations (SDLFs). Generally, an emulsified dosage form is rapidly absorbable; therefore, it makes sure that a poorly water-soluble drug is...
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IMPORTANCE OF THE FIELD Since the 1950s, ultrasonic nebulizers have played an important role in pulmonary drug delivery. As the process in which aerosol droplets are generated is independent and does not require breath-actuation, ultrasonic nebulizers, in principle, offer the potential for instantaneously fine-tuning the dose administered to the specific requirements of a patient, taking into a...
متن کاملLipid-Based Drug Delivery Systems
The principle objective of formulation of lipid-based drugs is to enhance their bioavailability. The use of lipids in drug delivery is no more a new trend now but is still the promising concept. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address challenges like the solubility and bioavailability of poorly water-soluble drugs. Lipid-based formulati...
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ژورنال
عنوان ژورنال: Chemical Physics
سال: 2021
ISSN: 0301-0104
DOI: 10.1016/j.chemphys.2021.111192